Regulation of bicarbonate by calcineurin and IRBIT in pancreas.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18992
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Keio University
• Principal Investigator: YAMAZAKI OSAMU 慶應義塾大学, 医学部(信濃町), 助教 (80757229)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 重炭酸 / トランスポーター / チャネル / リン酸化・脱リン酸化 / 細胞内塩素イオン濃度

Outline of Final Research Achievements

Pancreatic excretion system contributes not only digestive systems but also keeping homeostasis. These system deficiency leads to pancreatitis, multiple organ failure, and pancreatic tumor progression.
Here we focused on IP3 receptor binding protein (IRBIT) and calcineurin. These protein acts as a master regulator of pancreatic excretion system, especially for sodium-bicarbonate co-transporter (NBCe1). Novel phosphorylation and dephosphorylation sites in NBCe1 coordinate to IRBIT and calcineurin, leads to fully activation of NBCe1 and bicarbonate excretion.
We submit these novel findings and there are revised in Science Signaling paper.

Free Research Field

生理学