Dissecting the functional role of a novel ligand for APJ, ELABELA, in cardio-renal connection

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19013
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Akita University
• Principal Investigator: SATO Teruki 秋田大学, 医学(系)研究科(研究院), 助教 (30733422)
• Co-Investigator(Renkei-kenkyūsha): Kuba Keiji 秋田大学, 大学院医学系研究科 分子機能学・代謝機能学講座, 教授 (10451915)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ELABELA / APJ / 心不全 / 心腎連関

Outline of Final Research Achievements

In this study, we investigated the functional role of a novel ligand for APJ receptor, ELABELA, in controlling heart function.　ELABELA has been identified as a second ligand for APJ receptor, while Apelin has been thought to be only ligand for APJ receptor. We showed that ELABELA-APJ axis protects from pressure overload-induced heart failure possibly via suppression of ACE expression. In addition, we analyzed the role of ELA in the renal collecting duct.

Free Research Field

循環器内科学