Molecular basis of angiogenesis regulated by CUL3-dependent membrane trafficking

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19038
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Ehime University
• Principal Investigator: Maekawa Masashi 愛媛大学, プロテオサイエンスセンター, テニュアトラック助教 (10771917)
• Research Collaborator: HIGASHIYAMA Shigeki 愛媛大学, プロテオサイエンスセンター, 教授 (60202272) ; SAKAUE Tomohisa 愛媛大学, 大学院・医学系研究科, 助教 (20709266) ; TAGUCHI Tomohiko 東北大学, 大学院・生命科学研究科, 教授 (10300881)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 血管新生 / CUL3 / 細胞内膜輸送 / Integrin β1

Outline of Final Research Achievements

Angiogenesis, the formation of new blood vessels, is related to not only development but a variety of diseases like tumor growth/metastasis. Anti-angiogenic drugs are successfully used for cancer therapy. In this study, we identified a novel angiogenic factor, the CUL3/ANKFY1 ubiquitin E3 ligase complex, which determines the cell surface level of integrin, an essential adhesion molecule for angiogenesis. CUL3/ANKFY1 regulated recycling of integrin from endosomes to the plasma membrane in human endothelial cells. The CUL3/ANKFY1 complex might be an attractive protein complex to develop novel anti-angiogenic drugs.

Free Research Field

腫瘍生物学