Elucidation of the functions and physiological relevance of novel autophagy regulator Rufy4 in immune regulation systems

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19043
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Osaka City University (2017); Osaka University (2016)
• Principal Investigator: TERAWAKI Seigo 大阪市立大学, 大学院医学研究科, 助教 (60437217)
• Research Collaborator: HIROI Takachika 東京都医学総合研究所, プロジェクトリーダー ; PIERRE Philippe Centre d'Immunologie de Marseille-Luminy, Director
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: オートファジー / 免疫制御 / 炎症疾患

Outline of Final Research Achievements

Autophagy is an indispensable degradation system for organisms by degrading and facilitating metabolism of intracellular components. In addition, it’s suggested that autophagy functions not merely as degradation system but also as regulator in immune system. We have previously identified a gene; Rufy4 which regulates autophagy especially in immune competent cells. This time, we established Rufy4 knockout mouse and analyzed its phenotype. We established bronchitis model and found that less inflammation response in Rufy4 deficient setting. These results suggested that Rufy4 function as a novel inflammation regulator and revealed that autophagy has more extensive role in immune regulations.

Free Research Field

分子細胞生物学、免疫学