2017 Fiscal Year Final Research Report
Development of glycobiological markers specific for normal mesothelium and mesothelioma.
| Project/Area Number |
16K19078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | University of Fukui |
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Principal Investigator |
Sakai Yasuhiro 福井大学, 学術研究院医学系部門, 特命助教 (20754394)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 硫酸化糖鎖 / 悪性中皮腫 |
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| Outline of Final Research Achievements |
We discovered that 6-sulfo sialic lactosamine (sLacNAc) is expressed on normal mesothelial cells and malignant mesothelioma cells by immunohistochemistry, high-performance liquid chromatography, and mass spectrometry. 6-sulfo sLacNAc is identified in various histological types of malignant mesothelioma; thus, the marker recognizing 6-sulfo sLacNAc is very useful to diagnose malignant mesothelioma pathologically. Moreover, some additional animal experiments revealed that this glycostructure is biosynthesized by some sulfotransferases including KSGal6ST, GlcNAc6ST-1, and GlcNAc6ST-2. This glycobiological findings include new aspects of the distribution of sulfated glycans.
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| Free Research Field |
糖鎖生物学
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