2017 Fiscal Year Final Research Report
Developing novel treatment of refractory cancer by targeting Liver X Receptor and its metabolism related gene
| Project/Area Number |
16K19083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
|
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| Research Institution | Dokkyo Medical University (2017)
Fukushima Medical University (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 癌代謝 / 核内受容体 / 難治性癌 |
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| Outline of Final Research Achievements |
We investigated of expression of Liver X Receptor (LXRα/β) in normal and refractory cancer tissues of the human lung and pancreas. The result showed that LXRβ was expressed in the
various epithelial cells of normal lung and pancreas tissues. Similarly, LXRβ was expressed in the refractory cancer tissues. We next examined the efficacy of LXR targeted drug against refractory cancer cell lines, but its positive results could not be obtained.
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| Free Research Field |
実験病理学
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