Pathways of colorectal carcinogenesis from serrated lesions (especially from traditional serrated adenomas).

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Hashimoto Taiki 国立研究開発法人国立がん研究センター, 中央病院, 医員 (40773875)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 大腸腫瘍 / WNT / 分子病理学 / SSA/P / 癌 / RNF43 / RSPO / MLH1

Outline of Final Research Achievements

We identified frequent WNT pathway gene mutations in colorectal sessile serrated adenoma/polyps (SSA/Ps) with dysplasia. SSA/Ps with dysplasia exhibit distinct clinicopathological and molecular features depending on the MLH1 statuses. It is suggested that WNT pathway gene mutations are associated with the presence of dysplasia in SSA/Ps and SSA/Ps progress to carcinoma via two distinct pathways depending on the MLH1 statuses in the early stages of carcinogenesis.
We proposed a novel type of colorectal polyps characterized by mixed adenomatous and serrated features with KRAS mutation and RSPO fusion/overexpression.

Free Research Field

病理学