2018 Fiscal Year Final Research Report
The role of mitochondrial fission protein DRP1 in intestinal tumorigenesis
| Project/Area Number |
16K19110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo (2018)
Tokyo Women's Medical University (2016-2017) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | ミトコンドリア |
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| Outline of Final Research Achievements |
To develop the new therapeutic approaches targeting mitochondrial dynamics, I focused on mitochondrial fission factor DRP1, which is reported to regulate survival of colorectal cancer cell lines. Intestinal tumor mouse model lacking DRP1 specifically in intestinal epithelial cells however develop tumors that was comparable to wild-type control mice.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
近年の研究成果により、ミトコンドリア形態の腫瘍制御への関与が明らかになりつつある。しかしながらそれらの知見の多くは癌細胞レベルの解析にとどまっている。本研究は、腸管腫瘍を自然発症するマウスモデルを用い、ミトコンドリア形態による腫瘍制御を個体レベルで検討した点において意義深い。
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