Exploring the small molecule inhibitors that specifically block the intracellular signal perturbation induced by Helicobacter pylori CagA oncoprotein

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19121
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: The University of Tokyo
• Principal Investigator: Hayashi Takeru 東京大学, 大学院医学系研究科(医学部), 助教 (10722209)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ヘリコバクター・ピロリ / CagA / 胃発がん

Outline of Final Research Achievements

X-ray crystal structure analysis and biochemical analysis revealed the structural mechanism underlying the deregulation of human pro-oncogenic phosphatase SHP2 by Helicobacter pylori virulence factor CagA at the atomic level. Based on the structural information, I then explored small-molecular inhibitors that can specifically block CagA-SHP2 interaction. Chemical screening using multiple compound libraries identified several candidates of the inhibitor for CagA-mediated SHP2 deregulation. This study is expected to be a research base leading to the innovative clinical application for prevention and early intervention of gastric cancer caused by H. pylori infection.

Free Research Field

生化学、分子腫瘍学