Functional elucidation of sRNA on the pathogenicity island of Helicobacter pylori.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19122
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Jichi Medical University
• Principal Investigator: Kiga Kotaro 自治医科大学, 医学部, 講師 (90738246)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ピロリ菌 / sRNA / 酸化ストレス / ノンコーディングRNA

Outline of Final Research Achievements

Chronic infection of Helicobacter pylori is closely related to the onset of gastritis, gastric ulcer, gastric cancer and MALT lymphoma. In this study, we found that a small RNA (sRNA) contributes to resist cytotoxicity caused by oxidative stress in Helicobacter pylori. Furthermore, we revealed that the sRNA stabilizes the expression of thioredoxin-related genes, which is important for oxidative stress response, by analyzing the gene expression of sRNA-deficient strain of H. pylori. Since knockout strain of the sRNA remarkably decreased the ability of H. pylori to colonise to the stomach, it was suggested that the sRNA is involved in gastric disease caused by H. pylori infection.

Free Research Field

細菌学