Investigation of obesity-related metabolic markers in plasma and urine using metabolome profiling

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19259
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Keio University
• Principal Investigator: Kurihara Ayako 慶應義塾大学, 医学部(信濃町), 助教 (40645470)
• Research Collaborator: Takebayashi Toru ; Harada Sei ; Takeuchi Ayano ; Okamura Tomonori ; Sugiyama Daisuke ; Iida Miho
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 内臓脂肪蓄積量 / 肥満 / メタボロームプロファイリング

Outline of Final Research Achievements

As a result of PLS discriminant analysis, the plasma metabolites related to the following four amino acid metabolic pathways contributed to obese distinction: glycine, serine and threonine metabolism, cysteine and methionine metabolism, phenylalanine metabolism, histidine metabolism. As for urine metabolites, two amino acid metabolic pathways were associated with obesity: phenylalanine metabolism, alanine, aspartate and glutamate metabolism. Metabolites of phenylalanine metabolism were commonly related to obesity in plasma and urine. The plasma lipid metabolites also contributed to obese distinction, especially regarding fatty acid biosynthesis, linoleic acid metabolism, biosynthesis of unsaturated fatty acids. We will continue with further examination while following the study subjects.

Free Research Field

栄養疫学