2018 Fiscal Year Final Research Report
Molecular mechanism of sarcopenia in cancer patients
Project/Area Number |
16K19310
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Gifu University |
Principal Investigator |
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Research Collaborator |
NINOMIYA SORANOBU
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Keywords | サルコペニア / トリプトファン / 癌 |
Outline of Final Research Achievements |
Our data show for the first time that tryptophan(Trp) deficiency underlies skeletal muscle atrophy in cancer-related sarcopenia, and we have established a direct link between cancer-related sarcopenia and Trp. Given that evaluations of cancer-related sarcopenia are useful for predicting the prognoses of some cancers and decision-making in relation to treatment strategies, we postulate that the serum Trp level might become a valuable biomarker of sarcopenia development and progression. The results from the present study also indicate that targeting the Trp and kynurenine pathway that is mediated by IDO, might be a promising tactic for preventing or treating sarcopenia in patients with cancer.
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Free Research Field |
腫瘍学
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Academic Significance and Societal Importance of the Research Achievements |
本研究による成果により、これまで十分明らかになっていなかった癌患者におけるサルコペニア発症機序の一因を示した。癌患者では発症早期よりアミノ酸バランス異常が起きており、特にトリプトファンの低下が報告されている。このトリプトファン欠乏が骨格筋萎縮を引き起こしていることがわかり、今後サルコペニア発症の予測因子、発症予防、さらには治療ターゲットとして臨床応用されることが期待される。
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