2017 Fiscal Year Final Research Report
Development of Ras Inhibitory Therapy for Chronic Liver Diseases
| Project/Area Number |
16K19330
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Chiba University (2017)
The University of Tokyo (2016) |
|---|
Principal Investigator |
Ryo Nakagawa 千葉大学, 大学院医学研究院, 特任研究員 (60594596)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 自己免疫性肝疾患 / Ras阻害剤 / リンパ球 |
|---|
| Outline of Final Research Achievements |
To develop a treatment for chronic liver diseases, I study about Ras-inhibitors. Then the autoimmune liver disease, especially primary biliary cholangitis (PBC) is seemed to be adopted to Ras-inhibitor therapy. In PBC-CD4+ T cells, upregulated N-Ras induced inflammatory cytokines. Then Ras-inhibitors suppressed inflammatory cytokines from CD4+ T cells by regulating N-Ras. Therefor, Ras-inhibitors could be an attractive and novel therapeutic option for PBC.
|
| Free Research Field |
肝臓額
|
