2018 Fiscal Year Final Research Report
Important roles of non-NO-mediated endothelium-dependent relaxation in cardiovasuclar disease
| Project/Area Number |
16K19383
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Godo Shigeo 東北大学, 医学系研究科, 大学院非常勤講師 (70763233)
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| Research Collaborator |
Shimokawa Hiroaki
Shiroto Takashi
Saito Hiroki
Ito Akiyo
Ikumi Yosuke
Kajitani Shoko
Sato Saori
Lerman Amir
Eaton Philip
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 血管内皮機能 / 内皮由来弛緩因子 / 内皮由来過分極因子 / 一酸化窒素 / 冠動脈硬化症 |
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| Outline of Final Research Achievements |
This study highlighted that vessel size-dependent contribution of nitric oxide (NO) and endothelium-derived relaxing factor (EDHF) played an important role in coronary microcirculation in mice. Moreover, this study demonstrated that coronary microvascular endothelial dysfunction (CMED) was associated with more advanced plaque characteristics in patients with chest pain and early nonobstructive coronary artery disease, and that CMED was an independent predictor of rupture-prone vulnerable plaques. These results indicate a potential role of CMED in the progression of coronary atherosclerosis in the early stage of the disease.
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| Free Research Field |
血管生物学, 循環器内科学
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢化社会に突入した我が国において心血管病は急速に増加傾向にある。本研究の成果により, 内皮依存性弛緩反応における血管径に応じた一酸化窒素 (NO) と内皮由来過分極因子 (EDHF) の生理的バランスの意義が明らかになり, 特に抵抗血管・微小循環におけるNOを介さない機序での血管恒常性の維持機構を解明することにより, 血管内皮機能と密接な関係にある心血管病の新たな治療戦略を開発に役立つ可能性がある。さらに, NOに依らないEDHFを介した微小循環における血管弛緩反応の重要性に着目している点に独創性と学術的意義がある。
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