The role of JCAD, an adhesion molecule of endothelial cell, in regulating thrombosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19406
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kobe University
• Principal Investigator: Hara Tetsuya 神戸大学, 医学研究科, 特命助教 (70547504)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 深部静脈血栓症

Outline of Final Research Achievements

１．We assessed the role of JCAD in the regulation of thrombus formation. Using IVC ligation model, we compared the DVT size between WT mice and JCAD knock out mice. JCAD knock-out mice exhibited significantly larger thrombus size compared to WT mice.
2. We then assessed the molecular mechanism of JCAD in thrombus formation. Western blotting analysis revealed that JCAD regulate the ERK signaling cascade in HUVEC after the VEGF (vascular endothelial growth factor) stimulation.

Free Research Field

循環器内科学