2017 Fiscal Year Final Research Report
Phenotype and biomarkers of the asthma COPD overlap syndrome
| Project/Area Number |
16K19450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
|
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| Research Institution | Kyoto University |
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Principal Investigator |
|
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | asthma / Eosinophilic / Smoking / Staphylococcal |
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| Outline of Final Research Achievements |
At first, the associations of inflammatory cell types and pulmonary function in patients with obstructive airway disease were investigated. We showed that
both eosinophilic and neutrophilic inflammation may be associated with airflow limitation in steroid-naive ex-smokers with asthma.
Next, the effects of the biomarkers on clinical indexes, including eosinophilic inflammation and lung function were assessed in smokers with asthma.The frequency of sensitization to SEs was significantly higher in current, ex-, and never smokers, in decreasing order. In current or ex-smokers with asthma, patients with sensitization to SEs exhibited higher blood eosinophil counts, greater airflow limitation, and more severe disease than those without sensitization to SE. A longer smoking abstinence period was associated with serum specific IgE levels to SEs. We showed that sensitization to SEs may be a marker of eosinophilic inflammation and disease severity in obstructive lung diseases.
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| Free Research Field |
asthma
|
