2017 Fiscal Year Final Research Report
Elucidation of pharmacokinetics of molecular targeted drugs by Imaging massspectrometry
| Project/Area Number |
16K19465
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
SOEJIMA Kenzo
YASUDA Hiroyuki
MASUZAWA Keita
ARAI Daisuke
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 肺癌 / 分子標的薬 / 腫瘍内代謝 |
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| Outline of Final Research Achievements |
We established a xenograft mouse model subcutaneously transplanted with a non-small cell lung cancer cell line. Next, we evaluated Intratumoral metabolism of xenograft mouse model using imaging massspectrometry after administration of angiogenesis inhibitor (BIBF 1120, bevacizumab). As a result of evaluation, BIBF 1120 and bevacizumab showed different effects on blood flow and intratumoral metabolism.
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| Free Research Field |
肺癌
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