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2017 Fiscal Year Final Research Report

Elucidation of pharmacokinetics of molecular targeted drugs by Imaging massspectrometry

Research Project

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Project/Area Number 16K19465
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionKeio University

Principal Investigator

Nukaga Shigenari  慶應義塾大学, 医学部(信濃町), 助教 (70645613)

Research Collaborator SOEJIMA Kenzo  
YASUDA Hiroyuki  
MASUZAWA Keita  
ARAI Daisuke  
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords肺癌 / 分子標的薬 / 腫瘍内代謝
Outline of Final Research Achievements

We established a xenograft mouse model subcutaneously transplanted with a non-small cell lung cancer cell line. Next, we evaluated Intratumoral metabolism of xenograft mouse model using imaging massspectrometry after administration of angiogenesis inhibitor (BIBF 1120, bevacizumab). As a result of evaluation, BIBF 1120 and bevacizumab showed different effects on blood flow and intratumoral metabolism.

Free Research Field

肺癌

URL: 

Published: 2019-03-29  

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