2017 Fiscal Year Final Research Report
Elucidation of pharmacokinetics of molecular targeted drugs by Imaging massspectrometry
Project/Area Number |
16K19465
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Keio University |
Principal Investigator |
|
Research Collaborator |
SOEJIMA Kenzo
YASUDA Hiroyuki
MASUZAWA Keita
ARAI Daisuke
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | 肺癌 / 分子標的薬 / 腫瘍内代謝 |
Outline of Final Research Achievements |
We established a xenograft mouse model subcutaneously transplanted with a non-small cell lung cancer cell line. Next, we evaluated Intratumoral metabolism of xenograft mouse model using imaging massspectrometry after administration of angiogenesis inhibitor (BIBF 1120, bevacizumab). As a result of evaluation, BIBF 1120 and bevacizumab showed different effects on blood flow and intratumoral metabolism.
|
Free Research Field |
肺癌
|