Elucidation of the pathophysiology of pulmonary nontuberculous mycobacteriosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19473
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: NAITO Keisuke 産業医科大学, 医学部, 修練指導医 (80739475)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 肺非結核性抗酸菌症 / clone library method / 複数菌感染

Outline of Final Research Achievements

NTM was cultured in 55 of 120 patients, and 52 (94.5%) of these 55 patients were positive for the clone library method. Among these 52 patients, BALF samples of 45 (86.5%) patients were occupied with a single phylotype of NTM (mono-phylotype group), and multiple phylotypes were detected (multi-phylotype group) in the rest 7 (13.5%) patients. The multi-phylotype group significantly included more patients with worsening chest CT findings (P =0.048), more patients requiring treatment (P=0.032), and fewer patients responding to antimycobacterial treatment (P=0.016) compared to the mono-phylotype group.
Patients with multi-phylotype NTM group tend to show worsening chest CT findings and lower response to antimycobacterial treatment and symptom improvement.

Free Research Field

呼吸器内科