2017 Fiscal Year Final Research Report
Protective role of magnesium in phosphate toxicity
| Project/Area Number |
16K19487
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | マグネシウム / リン / 慢性腎臓病 / klotho |
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| Outline of Final Research Achievements |
Excess phosphate aggravates renal injuries. We have previously reported that magnesium attenuates phosphate-induced tubular cell injuries. Here we studied in vivo effects of magnesium on kidney injuries induced by high-phosphate diet. We found that increasing dietary magnesium improved kidney injuries caused by high phosphate diet. In addition, downregulation of renal αKlotho expression by high phosphate diet was restored by increasing dietary magnesium intake.
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| Free Research Field |
マグネシウム
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