The anti-obese and life-extending effect of AGF

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19541
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: Sugizaki Taichi 熊本大学, 大学院生命科学研究部(医), 研究員 (00468480)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 肥満 / Angptl6/AGF / エネルギー代謝 / メタボリックシンドローム

Outline of Final Research Achievements

There is no anti-obesity medicine with directly sufficient efficacy and safety guaranteed. Obesity, however, is on an increasing trend globally, and along with the progress thereof, various problems such as an increase in obesity-related diseases, including cardiovascular diseases and type 2 diabetes, shortened healthy life span and an increase in medical economic burden, etc. We have focused on AGF (angiopoietin-related growth factor) which is one of the angiopoietin-like protein family and a new physiologically active factor suggested to be associated with metabolic syndrome, etc. and have clarified some anti-obesity action of AGF. In this project, we investigated the mechanism of anti-obesity action of AGF and its effect on extending life span.

Free Research Field

代謝学