2017 Fiscal Year Final Research Report
Role of DENND2A for development of neuroblastoma
| Project/Area Number |
16K19644
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
Nishimura Noriyuki 神戸大学, 大学院, 特命教授 (00322719)
Mori Takeshi 神戸大学, 大学院, 特命講師
Kosaka Yoshiyuki 兵庫県立こども病院, 血液腫瘍内科部長
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 神経芽腫 / がん幹細胞 / DENND2A / Rab9B / 細胞内小胞輸送 |
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| Outline of Final Research Achievements |
Neuroblastoma is a typical recurrent and refractory tumor in children and its long-term survival remains less than 40%. Neuroblastoma relapse is caused by activation of chemo-resistant cancer stem cells (CSCs). Key regulators of intracellular vesicle trafficking, DENN domain proteins, were implicated in this process. In this study, a member of DENND domain proteins DENND2A and its target Rab family small G protein Rab9B were found to be involved in the development and progression of neuroblastoma.
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| Free Research Field |
小児血液腫瘍学
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