The effect of oral immunotherapy on class switching and change in avidity of allergen-specific immunoglobulin

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19648
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: SUGIMOTO Mayumi 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (20771314)
• Research Collaborator: KIDO Hiroshi
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 食物アレルギー / 経口免疫療法 / 抗原特異的免疫グロブリン

Outline of Final Research Achievements

This study aims to identify the factors which predict the therapeutic effects and to elucidate the mechanism of oral immunotherapy (OIT) by measuring serum allergen-specific immunoglobulins. The response to OIT was associated with significant increases in serum allergen-specific IgG1 levels after up-dosing phase and high baseline IgA levels, compared with small changes in immunoglobulin response in low-responders. The characteristic IgG1 changes and IgA levels in the responders could be potentially useful biomarkers for the prediction of positive clinical response to OIT. The avidity of allergen-specific IgE after OIT was also significantly decreased in high-responders, suggesting that it might be involved in the mechanism of OIT.

Free Research Field

アレルギー学