2017 Fiscal Year Final Research Report
Basic research for the inhibition of GVHD due to CCL8 deficiency
| Project/Area Number |
16K19658
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
|
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| Research Collaborator |
KOKAI Yasuo
HORI Tsukasa
YAMAMOTO Masaki
SAITOU Makoto
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 急性移植片対宿主病 / CCL8 / 造血幹細胞移植 |
|---|
| Outline of Final Research Achievements |
Acute graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (all-HSCT). To elucidate a possible role of CCL8 in acute GVHD pathology, we performed murine lethal acute GVHD models of allo-HSCT using CCL8 knockout mice.
As a result, the early mortality of the models using CCL8 knockout mice as either recipients or donors is markedly reduced compared to those of wild type control. The early mortality of the models using CCL8 knockout mice as both recipients and donors was not improved.
This observation suggests CCL8 is closely involved in acute GVHD pathology.
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| Free Research Field |
小児血液腫瘍学
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