Epithelial mesenchymal transition in wound edge keratinocytes

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19727
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Nagasaki University
• Principal Investigator: KOIKE Yuta 長崎大学, 医歯薬学総合研究科(医学系), 助教 (10530412)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 皮膚再生学 / 上皮間葉移行 / ＥＭＴ / ＦＧＦ2

Outline of Final Research Achievements

During reepithelialization of the wound healing process, keratinocytes at leading edge of the wound edge are migrating in association with a transition into spindle cells and a reduction of cell-cell contact. These phenomena are thought to belong to epithelial mesenchymal transition (EMT). We examined bFGF effects on EMT at wound edge keratinocytes using mouse dorsal skin. As a result, EMT of keratinocytes at leading edge are enhanced with bFGF treatment and EMT inducer cytokines and transcriptional factors were also upregulated with bFGF.

Free Research Field

皮膚科学