2017 Fiscal Year Final Research Report
The role of lncRNA in pathogenesis of dermatomyositis
| Project/Area Number |
16K19729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
AKI Ogata 熊本大学, 医学部附属病院, 非常勤診療医師 (80433035)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 皮膚筋炎 / long non cording RNA |
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| Outline of Final Research Achievements |
Polymyositis and dermatomyositis are inflammatory muscular diseases of unknown origin, muscle, lung, and skin become the mainstay of lesions and rapid progressive interstitial pneumonia affects the prognosis of life. The skin symptoms seen in dermatomyositis are diverse, difficult to diagnose, occasionally refractory, and often do not respond to conventional treatment. The detailed mechanism of eruption is unknown and its elucidation may lead to early diagnosis and new treatment. We confirmed that lncRNA (dio3os, NTT) is elevated in the sera and tissues of DM patients and tried to elucidate the role of lncRNA in dermatomyositis.
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| Free Research Field |
膠原病
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