2017 Fiscal Year Final Research Report
Comprehensive analysis of the synaptotagmin gene family in drug-induced parkinsonisms.
| Project/Area Number |
16K19775
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 統合失調症 / 薬剤性パーキンソニズム / シナプトタグミン |
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| Outline of Final Research Achievements |
We performed a comprehensive mutation analysis of the synaptotagmin gene family in schizophrenic patients with drug-induced parkinsonisms. We found a novel heterozygous mutation, c.-18+47G/A, in intron 4 of the Synaptotagmin 1 gene in a patient with drug-induced dystonia.
In addition, we found different patterns of drug-induced parkinsonisms in 22q11.2 deletion syndrome patients with schizophrenia-like psychosis.
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| Free Research Field |
分子精神医学
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