Establishment of Revolutionary Molecular Fluorescence Imaging Method in core needle biopsy of breast cancer for Genome and Precision Medicine

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19904
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Showa University
• Principal Investigator: Takamaru Tomoko 昭和大学, 医学部, 講師 (00404624)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 蛍光プローブ / 分子イメージング

Outline of Final Research Achievements

Fluorescence imaging has now attracted a great interest as a new method of real-time cancer diagnosis. The aim of this study is to evaluate the diagnostic performance of the probe for breast cancer. We investigated theγGlu-HMRG activity using the specimens obtained by core needle biopsy (CNB) or vacuum-assisted breast biopsy (VAB).
The differential ability between cancer and benign was 70% in sensitivity and 61% in specificity. It was possible to distinguish between invasive cancer and benign tumor, while differential diagnosis between invasive cancer and non-invasive cancer, or benign tumor and non-invasive cancer was difficult.In addition, ER negative, ki67 high value, and HER2 type had high fluorescence intensity in invasive cancer.

Free Research Field

乳腺外科

Academic Significance and Societal Importance of the Research Achievements

本蛍光プローブを用いることにより、検体採取後直ちに目的とする部位（癌組織）が含まれていることを確認することができる。これはサンプリングエラーを防ぐことにつながり、不要な再生検を防ぐことができる。また、治療方針決定に有用なサブタイプやバイオマーカー等の推定も可能となり、早期に治療を開始可能となることが期待される。