Comprehensive analysis of gene mutation and expression profiles in neuroendocrine carcinoma of the stomach

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19960
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Shizuoka Cancer Center Research Institute
• Principal Investigator: MAKUUCHI Rie 静岡県立静岡がんセンター(研究所), その他部局等, 医師 (50723235)
• Research Collaborator: TERASHIMA Masanori ; NAKAJIMA Takashi ; KUSUHARA Masatoshi ; URAKAMI Kenichi ; SERIZAWA Masakuni ; HATAKEYAMA Keiichi
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 胃癌 / 神経内分泌細胞癌 / 遺伝子発現 / 遺伝子変異

Outline of Final Research Achievements

We found that neuroendocrine carcinoma (NEC) of the stomach showed a significantly higher average number of somatic mutations per tumor than gastric adenocarcinoma. In particular, TP53 mutation was more frequently observed in NEC than in adenocarcinoma, and genes related to the nervous system were more frequently mutated in NEC.
Moreover, NEC and adenocarcinoma were found to be completely different tumors based on gene expression profiles and 40% of the genes expressed strongly in NEC were related to the nervous system. CPLX-2 (Complexin-2) was detected as one of the genes which may contribute to the differences between NEC and adenocarcinoma. CPLX-2 was exclusively expressed in NEC, as demonstrated by immunohistochemistry, and is suggested to be a potential novel biomarker for the diagnosis of NEC.

Free Research Field

外科学