Elucidation of pathogenesis of secondary aorto-esophageal fistula and construction of early diagnosis system

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19963
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Tohoku University
• Principal Investigator: Hayatsu Yukihiro 東北大学, 大学病院, 助教 (50747433)
• Research Collaborator: Katahira Shintaro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 二次性大動脈食道瘻 / LDF / TEVAR

Outline of Final Research Achievements

This study aimed to demonstrate the reduction of the esophageal mucosal blood flow after thoracic stent-graft insertion and the clinical utility of esophageal blood flow sensor probe in clarifying the mechanisms underlying secondary aorto-esophageal fistula. In addition, this study aimed to establish the indication criteria for the prevention or early surgical intervention of secondary aorto-esophageal fistula. The esophageal blood flow sensor probe was developed, and an evident decrease in the esophageal mucosal blood flow in the acute phase after thoracic stent-graft insertion was demonstrated, thereby proving some of the hypotheses. Further, upon confirmation of the durability and safety of the device, it can be utilized for clinical applications, and the purpose of this research can be achieved.

Free Research Field

心臓血管外科

Academic Significance and Societal Importance of the Research Achievements

今後増加するであると考えられる、胸部ステントグラフト治療後に発生する致死的合併症の二次性大動脈食道瘻の病因の一部を実験的に証明し得た。本実験に使用した新規デバイスを臨床応用することで、二次性大動脈食道瘻の早期発見・予防法の確立へ向け前進することができた。