2017 Fiscal Year Final Research Report
Spasticity reduction trial by caveolin 1 over-expression therapy; Rat ischemic paraplegia model
| Project/Area Number |
16K19969
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Kamizato Kota 琉球大学, 医学(系)研究科(研究院), 助教 (10554454)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 対麻痺 / カベオリン |
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| Outline of Final Research Achievements |
Rat motor dysfunction model (hind-limb paraplegia model) were chosen in our study. Neuro growth factor (caveolin 1) were provided to remaining neurons by intracellar caveolin production. Subpial injection was used for virus delivery. It is new and efficient method for gene delivery.
Axonal grow from remained neurons were confirmed. We can not show motor recovery with caveolin over expression in rat paraplegia model.
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| Free Research Field |
神経科学
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