Establishment of a new treatment for dural arteriovenous fistula based on angiogenic factors

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19994
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: University of Tsukuba (2017-2018); National Cardiovascular Center Research Institute (2016)
• Principal Investigator: Ito Yoshiro 筑波大学, 附属病院, 病院講師 (90733014)
• Research Collaborator: Watanabe Daisuke ; Takigawa Tomoji ; Sato Masayuki ; Marushima Aiki ; Tsuruta Wataro ; Hayakawa Mikito ; Takano Shingo ; Ishikawa Eiichi ; Matsumaru Yuji ; Matsumura Akira
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 血管新生因子 / 硬膜動静脈瘻

Outline of Final Research Achievements

Although the animal model was constructed by anastomizing the jugular vein and the internal carotid artery and occluding the sinus, it was difficult to find out the possibility of medical treatment in animal experiments. The blood of the lesion in the case of dural arteriovenous fistula was collected to verify the expression of angiogenic factors. The expression of angiogenic factors in the lesion was comprehensively measured using the antibody array kit. In the cavernous sinus lesions, the expression of VEGF-R3, IL1β, MMP9, and uPAR was suppressed in Aggressive type compared to Benign type. No factor was found to be upregulated in either Aggressive type or Benign type.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

硬膜動静脈瘻の疾患発生と病態進行には従来考えられていた血管新生因子の高発現だけが関与するのではなく、血管新生因子の発現抑制や抑制系因子の発現が関与することを明らかにした。
関連した血管新生因子を定量的解析することで、硬膜動静脈瘻の発生や進行に関与している血管新生因子を同定することができる。さらには関与している血管新生因子に対する治療を行うことでこれまでは血管内治療では難治であった症例に対しても内科治療が奏功する可能性がある。