2017 Fiscal Year Final Research Report
The effect of cilostazol on thrombosis and atherosclerosis in DM patients
Project/Area Number |
16K20002
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Gifu University |
Principal Investigator |
Miyai Masafumi 岐阜大学, 医学部附属病院, 医員 (60613502)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | シロスタゾール / 糖尿病 / 血小板活性化 / 血小板凝集能検査 |
Outline of Final Research Achievements |
In the present study, we conducted an investigation into the effect of cilostazol on the phosphorylation of heat shock protein 27 (HSP27) and the release of platelet factor 4 and soluble CD 40ligand from collagen-activated platelets in type 2 diabetes mellitus (DM) patients. It was demonstrated that the rate of platelet aggregation was reduced up to 1.0 micro M, and the levels of phosphorylated-HSP27 (Ser-78 and Ser-82) were also attenuated after cilostazol adminstration.The released platelet factor 4 and soluble CD 40ligand levels from collagen-stimulated platelets were reduced by administration of cilostazol. These results strongly suggest that cilostazol inhibit collagen-induced activation of platelets through attenuation of phosphorylated-HSP27 and release of platelet factor 4 and soluble CD 40ligand in type 2 DM patients.
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Free Research Field |
脳神経外科
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