2017 Fiscal Year Final Research Report
moleculs related to fatty acid metabolism in glioma
| Project/Area Number |
16K20016
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Saga University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | glioma / CPT1C / FASN / metformine |
|---|
| Outline of Final Research Achievements |
We study fatty acid synthase (FASN) and carnitine palmitoyltransferase 1C(CPT1C) related to fatty acid metabolism in human gliomas.We performed an expression of mRNA by using Real-time PCR.In human glioma cell lines, Both mRNA of FASN and CPT1C increased in glucose-free medium. Metformine is known a drug with effect of anticancer agent.In the medium administrated to metformine,mRNA of CPT1C increased in the human glioma cell lines.
|
| Free Research Field |
脳腫瘍
|
