Contribution of glycinnergic neurons to spinal plasticity in neuropathic pain

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20083
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Niigata University
• Principal Investigator: KUEABE MIYUKI 新潟大学, 医歯学総合病院, 助教 (30635579)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 脊髄 / 痛み / in vivoパッチクランプ

Outline of Final Research Achievements

Little is known about the role of glycineergic neuron of spinal dorsal horn in neuropathic pain. We analyzed changes of inhibitory neuronal transmission between normal rats and neuropathic pain model rats using in vivo patch-clamp technique. As a result, only the amplitude of the inhibitory postsynaptic current decreased. There was no difference in the frequency and amplitude of glycineergic IPSC between the two groups. Furthermore, in model rats relative GABAergic neurons increased. The balance changes of these inhibitory neurons were thought to play a part of plasticity change in neuropathic pain.

Free Research Field

痛み