2017 Fiscal Year Final Research Report
Development of cyclic peptides for GPNMB of advanced invasive bladder cancer
| Project/Area Number |
16K20124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
|
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| Research Institution | University of Tsukuba |
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Principal Investigator |
|
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 膀胱癌 / 環状ペプチド / GPNMB |
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| Outline of Final Research Achievements |
I started to study in order to develop cyclic peptides specially binding to GPNMB which could lead new tests and treatments in clinical setting. First, I made the GPNMB protein and that with point mutation at hemITAM to synthesize cyclic peptides. The hemITAM is one of the very important domains to have function of invasion at bladder cancer. After getting the proteins, I generated some expression vectors to do screening the GPNMB specifically binding peptides among various candidates. After that, I found some peptides which can specifically binding to GPNMB. Through several expreiments, I got some cyclic peptides which could strongly bind to GPNMB. I continue this project, checking the cyclic peptides whether it is safe or not, where it locates, and so on.
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| Free Research Field |
膀胱癌
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