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2017 Fiscal Year Final Research Report

Basic study for development of overactive bladder treatment targeting 5-HT3 receptor-positive cells.

Research Project

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Project/Area Number 16K20135
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

Takezawa Kentaro  大阪大学, 医学系研究科, 招へい教員 (90648015)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywords5-HT3受容体 / 過活動膀胱
Outline of Final Research Achievements

In this study, I investigated the role of the 5-HT3 receptor in bladder function. First, I revealed that 5-HT3 receptors were expressed in the course of micturition reflex abundantly. In this process, I found 5-HT3 receptor-positive cells in bladder muscular layer. These cells were regarded as ganglionic neurons of parasympathetic nerves. These results suggested that the 5-HT3 receptor has significant roles for the bladder function. Next, I performed functional analysis. I revealed that 5-HT3 receptor agonist decreased mouse bladder volume. Therefore, the 5-HT3 receptor was suggested to be associated with the pathological condition of the overactive bladder.

Free Research Field

排尿障害

URL: 

Published: 2019-03-29  

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