2017 Fiscal Year Final Research Report
New treatment strategy in eosinophilic rhinosinusitis based on anti-oxidant reaction
| Project/Area Number |
16K20278
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | Superoxide dismutase / 好酸球性副鼻腔炎 / 鼻茸 / Laser microdissection / リモデリング |
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| Outline of Final Research Achievements |
The SOD activity was examined in the eosinophilic and non-eosinophilic CRS with nasal polyps as well as control sinus mucosa. The results can be summarized as follows: i) the SOD activity of the CRS groups was significantly decreased compared with that of the controls; ii) immunostaining of both CuZnSOD and MnSOD of the eosinophilic group was significantly decreased compared with that of the non-eosinophilic and control groups; iii) CuZnSOD mRNA of the eosinophilic group was significantly decreased compared with that of the control; iv) MnSOD mRNA of the eosinophilic group was significantly decreased compared with those of the non-eosinophilic and control groups. In conclusion, a disrupted balance between the oxidant generation mediated by recruited eosinophils and the oxidant defense system of SOD is suggested to play an important role in the formation and exacerbations of CRS with nasal polyps.
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| Free Research Field |
耳鼻咽喉科学
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