CSPG4 is a putative cancer stem cell marker and potential therapeutic target of HNSCC

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Izumiyama Keiko 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 共同研究員 (60774031)
• Research Collaborator: TANAKA Nobuyuki 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 頭頸部癌 / 癌幹細胞

Outline of Final Research Achievements

CSPG4 is a potential marker of head and neck cancer stem cells, and it’s potential in future cancer therapy was investigated. Introduction of CSPG4-expression vector into cancer cells resulted in appearance of multiple bands respresenting heavily glycosylated forms as well as degradation products. Expression of CSPG was not strictly restricted in cancer stem cells, and malignant cancer cells expressed CSPG4. Therefore, CSPG4 is a potential therapeutic target of head and neck cancer including a CAR-T cell therapy.

Free Research Field

頭頸部腫瘍学