Elucidation of spontanious regression mechanisms of neuroblastoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Kyushu University
• Principal Investigator: Harada Yui 九州大学, 薬学研究院, 助教 (00608507)
• Co-Investigator(Renkei-kenkyūsha): KAWAKUBO Naonori 九州大学, 大学病院, 助教 (90711185)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 神経芽腫 / 自然退縮 / MYCN / 自然抗体

Outline of Final Research Achievements

As a result of investigation of spontaneous regression rate using various depletion antibodies using neuroblastoma model mouse (human MYCN Tg mouse), the influence of CD4 positive T cell, CD8 positive T cell, NK cell is negligible It became clear that it was.
On the other hand, there was a positive correlation between natural antibodies produced by B cells in the peritoneal cavity, especially IgM and IgG3 blood levels and spontaneous regression, and it was also confirmed that there had CDC activity. However, it was suggested that these antibodies are useful as biomarkers of regression but are not as effectors thereof. Further examination of the influence of the transitional antibody from the mother is thought to be necessary.

Free Research Field

腫瘍免疫学