Analysis of hyperbaric oxygen therapy for severe soft tissue injury

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20382
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Gifu University
• Principal Investigator: Kanda Norihide 岐阜大学, 医学部附属病院, 助教 (40421177)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 高気圧酸素 / 薬物血中濃度 / 軟部組織損傷

Outline of Final Research Achievements

Recently, a new trauma management for soft tissue injury is in progress. However, it often causes necrosis and wound infection due to ischemia. Previous reports suggested that hyperbaric oxygen therapy (HBO) had anti-infection and wound healing effects for soft tissue injury. Conversely, its mechanism is still unknown. In this study, HBO-treated group was conducted HBO (100%, 2ATA) for 90 minutes. In septic mouse and wound healing rat, direct anti-infection and wound healing effects for soft tissue injury could not be observed using HBO. However, we confirmed that tissue concentration of a meropenem in HBO-treated mouse was more increased compared no-treated mouse. In conclusion, our data suggested that increasing tissue concentration of a medicine after HBO may contribute to the healing of the soft tissue injury

Free Research Field

救急医学