2017 Fiscal Year Final Research Report
Metobolomic dynamics of microwave-induced traumatic brain injury in rat
| Project/Area Number |
16K20404
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 頭部外傷 / マイクロ波 / 脳損傷 |
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| Outline of Final Research Achievements |
Effect of microwave on brain have been studied because microwave is widely used, but effect of high energy microwave on brain has not been studied yet. We developed animal model in rat to reveal pathophysiology of microwave-induced traumatic brain injury (TBI). This study was to reveal metabolomic dynamics after high energy microwave exposure. Glutamate and aspartate, which were reflected as excitatory damage, decreased 0.8 (P = 0.005) and 0.9 (P = 0.035) times at an hour after exposure as compared with controrl. Triphosphate including ATP, CTP, GTP, UTP significantly decreased 0.3 (P = 0.002), 0.3 (P = 0.0005), 0.4 (P = 0.001), and 0.3 (P = 0.0005) times at an hour after exposure. Glycerophosphocholine, which was reflected as membrane turnover, at 24 hours after exposure decreased 0.8 times (P = 0.007).
Microwave-induced TBI has many common metabolic change in comparison with TBI.
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| Free Research Field |
救急医学
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