Establishment of novel radiosensitization based on radiation-induced G2 arrest modified by CAM/ECM

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20436
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KAIDA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (40632097)
• Co-Investigator(Renkei-kenkyūsha): MIURA Masahiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10272600)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 固形腫瘍 / 腫瘍内微小環境 / CAM/ECM / 放射線治療 / G2アレスト / 化合物スクリーニング

Outline of Final Research Achievements

In this study, I revealed the effect of some adhesion factors on radiation-induced G2 arrest kinetics using fluorescent ubiquitination-based cell cycle indicator (Fucci). However, I could not identify the factor determining cell cycle kinetics following the irradiation. In addition, I identified some chemical candidates affecting radiation-induced G2 arrest by using a chemical library composed of 1073 function-known compounds. It is well-known that DNA repair contributes to radiation-induced cell cycle kinetics. Therefore, I will examine whether the candidates can be applied as a radiosensitizer or not, and establish a novel radiosensitization targeting its factor.

Free Research Field

放射線生物学