Effect of QQ-MNC transplantation on BRONJ-like lesions in mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20510
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Nagasaki University
• Principal Investigator: NAKAJIMA Kazunori 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (40707246)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ビスフォスフォネート製剤 / QQ-MNC / BRONJ / 細胞治療 / 創傷治癒 / 治療法

Outline of Final Research Achievements

It has been reported that bisphosphonate-related osteonecrosis of the jaw (BRONJ) occurred in patients taking oral and/or intravenous bisphosphonates. However, the exact mechanisms of BRONJ are not clear. Moreover, definitive treatment strategies of BRONJ have not been developed. On the other hand, it has been demonstrated that epithelial progenitor cells (EPCs) exist in bone marrow. They plays important roles in anti-inflammatory and angiogenesis effects on injured tissues. Recently, effective culture method of EPCs has been developed, called as QQ-MNCs. The aim of this study was to investigate the effects of QQ-MNC transplantation on BRONJ-like lesions in mice. QQ-MNC transplantation positively affected soft tissue wound healing of tooth extraction sockets by upregulating angiogenesis, promoting collagen production and decreasing infiltration of polymorphonuclear cells. Therefore, QQ-MNC transplantation would become a treatment method of BRONJ.

Free Research Field

補綴系歯学