2017 Fiscal Year Final Research Report
Development of new bone regeneration therapy using cytokine cocktail derived from dedifferentiated fat cells (DFAT)
| Project/Area Number |
16K20541
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | DFAT / BMP-9 / 骨再生 / 歯周病 / ADSC |
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| Outline of Final Research Achievements |
The purpose of this study was development of new bone regenerative therapy for lost bone tissues due to periodontal and oral disease by using de-differentiated fat cells(DFAT) culture supernatant of bone morphogenetic protein(BMP)-9 and FK506 costimulation. In vitro study demonstrated that BMP-9 and FK506 costimulation induces increase of various cytokine in rat DFAT cells culture supernatant. Furthermore , we demonstrated that rDFAT cells culture supernatant of BMP-9 and FK506 costimulation have bone regenerative potential in rat calvarial defects model.
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| Free Research Field |
歯周病学
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