Premetastatic niche formation by circulating tumor endothelial cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20554
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: Maishi Nako (間石奈湖) 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 腫瘍血管新生 / 腫瘍血管内皮細胞 / 転移

Outline of Final Research Achievements

It is reported the formation of supportive metastatic microenvironment, referred to as premetastatic niche, before arrival of metastatic cells. Tumor endothelial cells, lining tumor blood vessels, is known to circulate in blood. In this study, we investigated the role of TECs in tumor metastasis. TECs adhered lung tissues more compared to normal endothelial cells when they were injected into mice intravenously. We established skin transplantation model using GFP mouse. Tumor cells were injected under the skin graft, and then we detected GFP positive cells in the blood of the mouse. We will examine the mechanisms of tumor metastasis by circulating TECs which secrete many cytokines.

Free Research Field

腫瘍血管新生