2017 Fiscal Year Final Research Report
The mechanism of BRONJ development by inflammation: The role of phosphate transporters.
| Project/Area Number |
16K20556
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Kiyama Tomomi 東北大学, 歯学研究科, 助教 (40756011)
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| Research Collaborator |
KAWAI Toshihisa
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ビスホスホネート / トランスポーター |
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| Outline of Final Research Achievements |
The aim of this project is to investigate the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ), by elucidating the mechanism of bisphosphonate’s cellular uptake, and the interrelationship between the transport mechanism and the inflammation. As the results, phosphate transporter SLC34 may be associated with the bisphosphonate’s cellular uptake and the transporter is increased with inflammation.
Therefore, there is the possibility that the inhibitor of phosphate transporter SLC34 can be useful for the treatment or prevention of BRONJ development.
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| Free Research Field |
口腔免疫学
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