Establishment of iPS cells derived from cleft lip and palate patient and osteogenic differentiation.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20619
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: Kato Hiroshi 東京歯科大学, 歯学部, 非常勤講師 (10755036)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: iPS細胞 / 唇顎口蓋裂 / 骨再生 / 骨芽細胞

Outline of Final Research Achievements

Cleft lip and palate (CLP) patients have alveolar bone defects, they need bone graft that allows maxillary arch continuity. Autogenous particulate cancellous bone and marrow harvested from iliac bone is still the gold standard because of the osteogenic properties. However, it has the risk of complications, we expect less invasive procedures using iPS technology. In this study, I established human iPS cells from a patient with non-syndromic CLP and examined osteogenic differentiation of them. In animal models with iPS cells transplantation, some new bone tissues were observed in the bone defects. It is suggested these cells may contribute to new bone regenerative therapies.

Free Research Field

口腔外科