2017 Fiscal Year Final Research Report
Glial control of neuronal excitability
Project/Area Number |
16K20917
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
Basic / Social brain science
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Research Institution | Tohoku University |
Principal Investigator |
Beppu Kaoru (下田) 東北大学, 医学系研究科, 非常勤講師 (40747458)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | アストロサイト |
Outline of Final Research Achievements |
Astrocytes release transmitters such as glutamate and lactate. We investigated how these transmitters are released from astrocytes. Excitatory neurons release glutamate and this glutamate activates glutamate transporters in astrocytes. Uptake of glutamate via glutamate transporters cause intracellular acidification in astrocytes. We found that ion flux and the resulting acidification trigger opening of volume-sensitive anion channels in astrocytes. Then glutamate anion is released through this channels. We also found that optogenetic alkalization of astocytes by photostimulation of archaerhodpsin in astrocytes enhanced extracellular lactate level. These results suggest that ion flux and the resulting pH fluctuation strongly regulates gliotransmitter release in astrocytes.
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Free Research Field |
神経科学
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