The study of functional analysis and therapeutic application of long-life neural stem cells derived from the adult hippocampus

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20957
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology; General physiology
• Research Institution: Chiba University
• Principal Investigator: YOSHIOKA KENTO 千葉大学, 大学院医学研究院, 特任助教 (50758232)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 神経幹細胞 / p38α / ポリイミド多孔質膜

Outline of Final Research Achievements

To know the molecular mechanism enabling the long-term maintenance of neural stem cells (NSCs) derived from the adult hippocampus and evaluate their possible therapeutic application, we conducted the following studies. (1) Based on the long-term maintenance of NSCs which might be promoted by p38α inhibition, the long-life NSCs labeled with fluorescent protein were transplanted into the cerebral cortex-injured mice. The transplanted cells were able to differentiate into neurons in the lesion area without tumorigenesis. (2) We have established a new method to maintain the activity of NSCs for a long time without either genetic disruption or pharmacological inhibition.

Free Research Field

医学