Molecular analysis of bone marrow failure syndrome modeled on donor derived bone marrow failure syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20973
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology; Tumor biology
• Research Institution: National Hospital Organization Nagoya Medical Center
• Principal Investigator: Yasuda Takahiko 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 (20723977)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 骨髄不全症候群 / 造血幹細胞移植 / ドナー由来 / 全エクソン解析

Outline of Final Research Achievements

We experienced four patients with bone marrow failure syndrome after allogeneic stem cell transplantation who sustain donor derived hematopoiesis. We aim to clarify a molecular mechanisms for development of bone marrow failure syndrome using specimens of patients of donor derived bone marrow failure syndrome. Whole exome sequencing revealed 5-10 somatic mutation with low allele frequencies in each patients. Low burden of clonal hematopoiesis with somatic mutations might be a characteristics of this complications after allogeneic stem cell transplantation.

Free Research Field

血液学